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Invitrogen
Human CCL2 (MCP-1) Recombinant Protein
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产品信息
14-8398-62
产品规格
Expression System
E. coli
分类
Recombinant
类型
Protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
Amount
5 µg
保存条件
-80°C
运输条件
Dry ice
产品详细信息
Description: CCL2, also known as Monocyte Chemotactic Protein-1 (MCP-1) and Monocyte Chemotactic and Activating Factor (MCAF), is a member of the β (CC) subfamily of chemokines. CCL2 is a chemoattractant for monocytes and regulates their adhesion molecule and cytokine expression patterns. It has also been shown to activate monocytes to be cytostatic for some human tumor cell lines. CCL2 is also capable of chemoattracting, activating and inducing histamine release from basophils. Recombinant human CCL2 produced inE. coli is a non-glycosylated peptide chain of 76 amino acids.
Applications Reported: Recombinant human CCL2 is biologically active.
Applications Tested: This recombinant human CCL2 has been tested in bioassays for chemoattractant activity. Measured by chemotaxis assay of human monocytes, the maximal chemoattractant activity was observed between 10-100 ng/mL.
Source: E. coli expressed amino acids Gln24-Thr99, accession number AAB29926.
Bioactivity: Measured by chemotaxis assay of human monocytes. Maximal chemoattractant activity was observed between 10-100 ng/mL.
Endotoxin: Less than 0.01 ng/ug cytokine as determined by the LAL assay. Purity: >98% as determined by SDS-PAGE.
Molecular Weight: 8.6 kDa.
Storage and handling: For best recovery, quick-spin vial prior to opening. Use in a sterile environment.
Purity: Greater than 90%, as determined by SDS-PAGE.
Aggregation: Less than 10%, as determined by HPLC.
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
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