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Invitrogen
Human EEA1 (aa 1391-1410) Synthetic Peptide
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产品信息
PEP-079
产品规格
分类
Synthetic
类型
Peptide
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.5 mg/mL once reconstituted
规格
50 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-079 is a 21 amino acid synthetic peptide whose sequence corresponds to amino acids 1391-1410 of the human EEA 1 protein. The sequence of this peptide is (amino to carboxy terminus): T (1391)-P- S- S- K- K- P- V- R- V- C- D- A- C- F- N- D- L-Q- G (1410)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human EEA 1, catalog # PA1-063A. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
Early endosomal antigen 1 (EEA1) is a 162 kDa membrane bound protein component specific to the early endosome and is essential for fusion between early endocytic vesicles. Early endosomes are cytoplasmic compartments which fuse with endocytic vesicles for redistribution of extracellular compounds to alternate destinations. Zinc-finger-like domains, reminiscent of those found in nucleic acid binding proteins, are located in the amino and carboxyl-terminal domains of EEA1. The carboxyl-terminal zinc-finger-like-domain is conserved in several other non-nuclear proteins, some of which are also involved in intracellular protein trafficking. In addition, this domain is an authentic zinc-binding domain and is critical to the intracellular localization of EEA1. Membrane association of EEA1 has been shown dependent on phosphatidyl 3-kinase activity, inhibitors of which cause EEA1 to dissociate from early endosomes.
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