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Invitrogen
Human FAM122B (aa 11-132) Control Fragment Recombinant Protein
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产品信息
RP-92011
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
EPDTSYGGTLRRSSSAPLIHGLSDLSQVFQPYTLRTRRNSTTIMSRHSLEEGLDMVNRETAHEREMQTAMQISQSWDESLSLSDSDFDKPEKLYSPKRIDFTPVSPAPSPTRGFGKMFVSSS
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
1M urea/PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (81%), Rat (81%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-51371. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
FAM122B (Family with Sequence Similarity 122 Member B) is a gene located on chromosome 9 that encodes a protein involved in cellular signaling and regulation. FAM122B is known to interact with protein phosphatase 2A (PP2A), a critical enzyme in multiple signaling pathways, thereby impacting various cellular functions such as growth, division, and apoptosis. This interaction is pivotal for the modulation of PP2A activity, which in turn influences numerous downstream signaling processes. Studies have indicated that FAM122B may play a role in cancer biology, particularly in the regulation of oncogenic pathways. Dysregulation of FAM122B expression has been observed in certain cancers, suggesting its potential involvement in tumor progression and as a biomarker for diagnosis or prognosis. Furthermore, the gene's expression patterns indicate its importance in normal cellular homeostasis and the maintenance of cellular signaling balance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: erg-3; ets-related; family with sequence similarity 122B; p55; PABIR family member 2; protein FAM122B; synoviocyte proliferation associated in collagen-induced arthritis 2; TMPRSS2/ERG fusion; unnamed protein product
基因别名: FAM122B; PABIR2; SPACIA2
UniProt ID: (Human) Q7Z309
Entrez Gene ID: (Human) 159090
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