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Invitrogen
Human Kir2.2 (KCNJ12) (aa 356-433) Control Fragment Recombinant Protein
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产品信息
RP-91128
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
RCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGGVLEQRPYRRESEI
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
1M urea/PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (79%), Rat (79%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-55485. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-sensitive inward rectifier potassium channel 12; Inward rectifier K(+) channel Kir2.2; Inward rectifier K(+) channel Kir2.2v; inward rectifier K(+) channel Kir2.6; IRK-2; Potassium channel, inwardly rectifying subfamily J member 12; potassium channel, inwardly rectifying subfamily J, member 12; potassium inwardly-rectifying channel, subfamily J, inhibitor 1
基因别名: hIRK; hIRK1; hkir2.2x; IRK-2; IRK2; KCNJ12; kcnj12x; KCNJN1; Kir2.2; Kir2.2v
UniProt ID: (Human) Q14500
Entrez Gene ID: (Human) 3768
