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Invitrogen
Human MAPKAPK3 (aa 343-381) Control Fragment Recombinant Protein
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产品信息
RP-105099
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
RVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSASQGCNN
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
1M urea/PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66156. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
MAPKAPK3 functions as an integrative element of signaling in both mitogen and stress responses. MAPKAPK3 functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MAPKAPK3 was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. MAPKAPK3 was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3pK; Chromosome 3p kinase; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; OTTHUMP00000210806; OTTHUMP00000210807
基因别名: 3PK; MAPKAP-K3; MAPKAP3; MAPKAPK-3; MAPKAPK3; MK-3
UniProt ID: (Human) Q16644
Entrez Gene ID: (Human) 7867
