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Invitrogen
Human MMP-14 (Prodomain-catalytic domain-hemopexin domain) His-tag Recombinant Protein
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产品信息
RP-77533
产品规格
Expression System
E. coli
分类
Recombinant
类型
Protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
Amount
10 µg
保存条件
-80°C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
RP-77533 is a purified His-tagged recombinant MT1-MMP/MMP-14 protein (prodomain, catalytic domain, and hemopexin domain) expressed in E.coli. RP-77533 may be used as a control with corresponding anti-MMP-14 antibodies. The pro-enzyme can be activated with trace amounts of the MT1-MMP catalytic domain.
靶标信息
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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