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Invitrogen
Human NDP Synthetic Peptide
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产品信息
PEP-0836
产品规格
分类
Synthetic
类型
Peptide
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
200 µg/mL
规格
50 µg
保存条件
-20°C
产品详细信息
This peptide corresponds to 18 amino acids near the amino terminus of human Norrin.
PEP-0836 can be used as a blocking peptide with polyclonal antibody PA5-20722.
靶标信息
NDP (Norrie disease protein), also known as norrin, is a secreted signaling protein encoded by the NDP gene that activates the canonical Wnt/β-catenin pathway by binding the Frizzled-4 (FZD4)/LRP5 receptor complex. It plays an essential role in retinal vascular development, maintenance of the blood-retina barrier, and inner ear vascularization. Loss-of-function variants in NDP cause Norrie disease and can also contribute to familial exudative vitreoretinopathy (FEVR).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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