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Invitrogen
Human RBM41 (aa 10-154) Control Fragment Recombinant Protein
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产品信息
RP-92118
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
SDEHVLEELETEGERQLKSLLQHQLDTSVSIEECMSKKESFAPGTMYKPFGKEAAGTMTLSQFQTLHEKDQETASLRELGLNETEILIWKSHVSGEKKTKLRATPEAIQNRLQDIEERISERQRILCLPQRFAKSKQLTRREMEI
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-60155. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
RBM41, known as RNA Binding Motif Protein 41, is identified as a novel component of the minor spliceosome, particularly interacting with its paralog, U11/U12-65K. Both RBM41 and U11/U12-65K share similar C-terminal RNA recognition motifs (RRMs), which are crucial for their role in spliceosomal activity. Distinctly, RBM41 has been associated with spliceosomal functions, although its precise cellular functions remain largely unexplored. Understanding the structural and functional parallels between RBM41 and U11/U12-65K aids in elucidating the mechanisms underlying minor spliceosome activity. The minor spliceosome itself is involved in the splicing of U12-type introns, thus playing a significant role in the regulation of gene expression. Additionally, RBM41's functional characterization in protein complexes and its involvement with RNA-binding activities enrich our understanding of gene regulation and cellular processes where the spliceosome plays a pivotal role. Research on RBM41 contributes to broader insights into RNA splicing and molecular genetics.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: RNA-binding motif protein 41; RNA-binding protein 41
基因别名: RBM41
UniProt ID: (Human) Q96IZ5
Entrez Gene ID: (Human) 55285
