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Invitrogen
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Highest antigen sequence indentity to the following orthologs: Mouse (76%), Rat (76%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58746. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DKFZp686P0776; E3 ubiquitin-protein ligase RNF6; ring finger protein (C3H2C3 type) 6; RING-H2 protein RNF-6
基因别名: RNF6; SPG2
UniProt ID: (Human) Q9Y252
Entrez Gene ID: (Human) 6049