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Gibco
Mouse IL-33 Recombinant Protein, PeproTech®
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产品信息
210-33-1MG
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human,
Mouse,
Non-human primate
Expression System
E. coli
分类
Recombinant
类型
Protein
偶联物
形式
Lyophilized
保存条件
-20°C
运输条件
Ambient
产品详细信息
210-33-1MG will be provided as 10 x 100 µg (210-33-100UG).
210-33-250UG will be provided as multiple 50 µg (210-33-50UG) and 100 µg (210-33-100UG) vials.
210-33-500UG will be provided as 5 x 100 µg (210-33-100UG).
Recombinant Murine IL-33 is a 17.5 kDa protein containing 158 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
靶标信息
IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules found in tonsils, Peyer's patches and mesenteric lymph nodes and is almost undetectable in placenta. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE. Studies have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine, and an intracellular nuclear factor with transcriptional regulatory properties.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
