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Invitrogen
Mouse PICK1 (aa 1-18) Synthetic Peptide
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产品信息
PEP-133
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
规格
50 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-133 is an 18 amino acid synthetic peptide whose sequence corresponds to amino acid residues 1-18 from mouse PICK1 protein. The sequence of this peptide is (amino to carboxy terminus): M (1)-F-A-D-L-D-Y-D-I-E-E-D-K-L-G-I-P-T (18).
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PICK1, catalog # PA1-073. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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