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Invitrogen
Rat Dynamin 1 (aa 633-647) Synthetic Peptide
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产品信息
PEP-042
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-042 is a 16 amino acid synthetic peptide whose sequence corresponds to amino acid residues 633-647 of rat dynamin I protein. The sequence of this peptide is (amino to carboxy terminus): (C)-K633-E-K-A-S-E-T-E-E-N-G-S-D-S-F647 (A cysteine residue was added to facilitate coupling KLH).
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat dynamin I, catalog # PA1-660. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
Reconstitute with 0.1 mL of distilled water.
靶标信息
Dynamin is a GTPase required for endocytosis of clathrin coated vesicles from the membrane. Dynamin's involvement in endocytosis was first discovered during the characterization of the temperature sensitive parylytic shibire mutation from Drosophila melanogaster. Three closely related isoforms have been identified in mammals. Dynamin1 is expressed exclusively in neurons, dynamin2 is ubiquitously expressed and dynamin3 is expressed primarily in the testes. Each of these isoforms of dynamin also has several splice variants. This suggests that each isoform/splice variant may have separate intracellular targets or function in the budding of distinct vesicle types. Common domain features of the dynamin proteins include an amino acid terminal GTPase domain, a central pleckstrin homology domain and a highly basic proline rich carboxyl terminus with several Src homology 3 (SH3) domains. These SH3 domains target the dynamin to the clathrin coated pit. Dynamin is known to interact with at least two proteins, AP2 adaptor protein complex and amphiphysin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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