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Invitrogen
11 alpha-hydroxyprogesterone Recombinant Mouse Monoclonal Antibody (1F1)
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11 alpha-hydroxyprogesterone Antibody (MA566664) in SDS-PAGE
SDS-PAGE characterization of 11 alpha-hydroxyprogesterone under reducing conditions. Lane M: Protein marker (kDa); Lane 11-α-OH-P: Purified 11 alpha-hydroxyprogesterone Recombinant Monoclonal (Product # MA566664). 11 alpha-hydroxyprogesterone showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-372.
产品信息
MA566664
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1F1
抗原
Conjugate of 11-alpha-OH-P hapten and KLH.
偶联物
形式
Liquid
浓度
8.2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
11 alpha-hydroxyprogesterone is a steroid hormone that serves as an intermediate in the biosynthesis of corticosteroids in the adrenal cortex. Structurally, it is a hydroxylated form of progesterone, exhibiting a hydroxyl group at the 11th carbon position, which contributes to its role in the metabolic pathways leading to the production of glucocorticoids such as cortisol. This compound is less well-known compared to other steroid intermediates, but it plays a crucial part in the complex chain of reactions in steroidogenesis. The presence of 11 alpha-hydroxyprogesterone is particularly significant in the context of certain enzymatic deficiencies, such as in congenital adrenal hyperplasia (CAH), where defects in steroid metabolism can lead to its altered levels. Ongoing research focuses on understanding the clinical implications of its levels and its utility in diagnosing and managing adrenal disorders through advanced biochemical assays.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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