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Proteintech
4EBP1 Monoclonal Antibody (2C3F3)
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产品信息
60246-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
2C3F3
抗原
4EBP1 Fusion Protein Ag18985 (1-118 aa encoded by BC004459)
偶联物
形式
Liquid
浓度
1.6 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MSGGSSCSQ TPSRAIPATR RVVLGDGVQL PPGDYSTTPG GTLFSTTPGG TRIIYDRKFL MECRNSPVTK TPPRDLPTIP GVTSPSSDEP PMEASQSHLR NSPEDKRAGG EESQFEMDI (1-118 aa encoded by BC004459 )
靶标信息
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 4E-BP1; eIF4E-binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; MGC431; MGC4316; P/OKCL.6; PHAS-1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1; translation initiation factor 4E binding protein 1
基因别名: 4E-BP1; 4EBP1; AA959816; BP-1; EIF4EBP1; PHAS-I
UniProt ID: (Human) Q13541, (Mouse) Q60876, (Rat) Q62622
Entrez Gene ID: (Human) 1978, (Pig) 100627508, (Mouse) 13685, (Rat) 116636
G1/S transition of mitotic cell cycle
IRES-dependent translational initiation
response to ischemia
insulin receptor signaling pathway
lung development
negative regulation of protein complex assembly
TOR signaling
response to ethanol
positive regulation of mitotic cell cycle
negative regulation of translational initiation
cellular response to hypoxia
regulation of translation
regulation of translational initiation
negative regulation of translation
