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Invitrogen
This Antibody was verified by Peptide array to ensure that the antibody binds to the antigen stated.
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:100-1:1,000 | - |
免疫组化（冰冻） (IHC (F)) |
Assay-dependent | - |
免疫沉淀 (IP) |
1:500 | - |
点杂交 (DB) |
Assay-dependent | - |
免疫电镜技术 (IM) |
Assay-dependent | - |
肽阵列 (Array) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Chemical |
宿主/亚型 |
Mouse / IgG2b |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
3I7 |
抗原 |
5-HydroxymethylCytosine / 5-hmC |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.81 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS |
内含物 |
no preservative |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2610634 |
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 5-hmc; 5-HydroxymethylCytidine; 5hmc; C5H7N3O2
