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Invitrogen
ABCG8 Polyclonal Antibody
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ABCG8 Antibody (PA5-78703) in ICC/IF
Immunocytochemistry analysis of ABCG8 using anti-ABCG8 antibody (Product # PA5-78703) . ABCG8 was detected in an immunocytochemical section of HepG2 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 5 μg/mL rabbit anti-ABCG8 antibody (Product # PA5-78703) overnight at 4°C. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was count... View More
产品信息
PA5-78703
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence in the middle region of human ABCG8 (328-371aa DRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDED).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HL-60 whole cell, human K562 whole cell, human HepG2 whole cell, rat liver tissue, rat PC-12 whole cell, mouse liver tissue, mouse HEPA1-6 whole cell. ICC/IF: HepG2 cell.
靶标信息
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. ABCG8, expressed at high levels in the liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols. The mutated form of this transporter can lead to sterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessive disorder, characterized by hyperabsorption of sterols and the inability to excrete sterols into bile.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-binding cassette sub-family G member 8; ATP-binding cassette, sub-family G (WHITE), member 8; ATP-binding cassette, subfamily G, member 8; MGC142217; sterolin 2; Sterolin-2; Sterolin2
基因别名: 1300003C16Rik; ABCG8; AI114946; GBD4; sterolin-2; STSL
UniProt ID: (Human) Q9H221, (Mouse) Q9DBM0, (Rat) P58428
Entrez Gene ID: (Human) 64241, (Mouse) 67470, (Rat) 155192
response to nutrient
excretion
negative regulation of intestinal phytosterol absorption
phospholipid transport
sterol transport
intestinal cholesterol absorption
cholesterol efflux
response to drug
cholesterol homeostasis
negative regulation of intestinal cholesterol absorption
transmembrane transport
transport
sterol homeostasis
metabolic process
regulation of intestinal cholesterol absorption
cholesterol transport
