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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:3,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant fragment corresponding to a region within amino acids 166 and 387 of ABH1 (Uniprot ID#Q13686) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
0.1M tris glycine, pH 7, with 20% glycerol |
内含物 |
0.01% thimerosal |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_11153474 |
Recommended positive controls: HeLa, NT2D1.
Predicted reactivity: Mouse (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: alkB, alkylation repair homolog 1; Alkylated DNA repair protein alkB homolog 1; alkylation repair, alkB homolog; Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA 6mA demethylase; DNA lyase ABH1; DNA N6-methyl adenine demethylase; DNA N6-methyl adenine demethylase ALKBH1; DNA oxidative demethylase ALKBH1; mRNA N(3)-methylcytidine demethylase; Nucleic acid dioxygenase ALKBH1
基因别名: ABH; ABH1; alkB; ALKBH; ALKBH1; hABH
UniProt ID: (Human) Q13686
Entrez Gene ID: (Human) 8846
分子生物学功能:
DNA metabolism protein
