Invitrogen

ACAP2 Polyclonal Antibody

Name: ACAP2 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-18209
Availability: InStock

查看其他12个ACAP2抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (4)

ACAP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 4

ACAP2 Antibody (PA5-18209) in IHC (P)

Immunohistochemistry analysis of ACAP2 in human lung. Samples were incubated with ACAP2 polyclonal antibody (Product # PA5-18209) using a dilution of 5 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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Immunogen image

Immunogen Image ACAP2 Polyclonal Antibody

产品信息

PA5-18209

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.3-1 µg/mL

免疫组化（石蜡） (IHC (P))

5-10 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide sequence (EKLNRFQQDSQKF) corresponding to the C-terminus amino acids of ACAP2 (aa 766-778).

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

100 µg

纯化类型

Ammonium sulfate precipitation, Antigen affinity chromatography

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_10977709

产品详细信息

This antibody is predicted to react with canine and porcine based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

靶标信息

ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.

仅用于科研。不用于诊断过程。未经明确授权不得转售。