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Peptide sequence: NPMNPKKYLG SFYTDALVHD PLSLKLLTDV IGKDKVILGT DYPFPLGELE
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 93%; Zebrafish: 93%
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
Protein Aliases: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Picolinate carboxylase
Gene Aliases: ACMSD
UniProt ID: (Human) Q8TDX5
Entrez Gene ID: (Human) 130013
Molecular Function:
decarboxylase
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