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Invitrogen
ACOX1 Recombinant Rabbit Monoclonal Antibody (K01_1M32)
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产品信息
MA563235
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_1M32
抗原
Recombinant protein of mouse ACOX1 (aa 1-270).
偶联物
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA
内含物
0.01% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MNPDLRKERA AATFNPELIT HILDGSPENT RRRREIENLI LNDPDFQHED YNFLTRSQRY EVAVKKSATM VKKMREFGIA DPEEIMWFKK LHMVNFVEPV GLNYSMFIPT LLNQGTTAQQ EKWMHPSQEL QIIGTYAQTE MGHGTHLRGL ETTATYDPKT QEFILNSPTV TSIKWWPGGL GKTSNHAIVL AQLITRGECY GLHAFVVPIR EIGTHKPLPG ITVGDIGPKF GYEEMDNGYL KMDNYRIPRE NMLMKYAQVK PDGTYVKPLS
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 97%, Pig - 89%, Cynomolgus monkey - 46%.
靶标信息
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACO; acyl-CoA oxidase 1, palmitoyl; acyl-CoA oxidase, straight-chain; acyl-Coenzyme A oxidase 1, palmitoyl; AOX; Palmitoyl-CoA oxidase; Peroxisomal acyl-coenzyme A oxidase 1; Peroxisomal fatty acyl-CoA oxidase; peroxisomal fatty acyl-coenzyme A oxidase; peroxisomal straight-chain Acyl-CoA oxidase; SCOX; Straight-chain acyl-CoA oxidase
基因别名: ACOX; ACOX1; AOX; D130055E20Rik; PALMCOX; Paox; RATACOA1; SCOX
UniProt ID: (Human) Q15067, (Rat) P07872, (Mouse) Q9R0H0
Entrez Gene ID: (Human) 51, (Rat) 50681, (Mouse) 11430
fatty-acyl-CoA binding
acyl-CoA dehydrogenase activity
acyl-CoA oxidase activity
receptor binding
electron carrier activity
PDZ domain binding
protein N-terminus binding
flavin adenine dinucleotide binding
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
fatty acid binding
palmitoyl-CoA oxidase activity
FAD binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase
very long-chain fatty acid metabolic process
generation of precursor metabolites and energy
lipid metabolic process
prostaglandin metabolic process
spermatogenesis
fatty acid oxidation
fatty acid beta-oxidation using acyl-CoA dehydrogenase
fatty acid beta-oxidation using acyl-CoA oxidase
alpha-linolenic acid metabolic process
fatty acid beta-oxidation
peroxisome fission
lipid homeostasis
positive regulation of cholesterol homeostasis
fatty acid metabolic process
metabolic process
oxidation-reduction process
