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Invitrogen
ACSL3/ACSL4 Recombinant Rabbit Monoclonal Antibody (HL1941)
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ACSL3/ACSL4 Antibody (MA5-56584) in WB
Western Blot analysis of ACSL3/ACSL4 using ACSL3/ACSL4 Recombinant Monoclonal Antibody (Product # MA5-56584). 293T, A431, HeLa, and HepG2 whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with ACSL3/ACSL4 antibody diluted at 1:1,000. A HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
MA5-56584
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1941
抗原
Recombinant fragment of human ACSL3 + ACSL4 protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
ACSL3 (Acyl-CoA Synthetase Long-Chain Family Member 3) and ACSL4 (Acyl-CoA Synthetase Long-Chain Family Member 4) are genes that encode enzymes belonging to the acyl-CoA synthetase family. These enzymes play crucial roles in lipid metabolism by catalyzing the activation of long-chain fatty acids through the formation of acyl-CoA. This process is essential for various cellular functions, including lipid biosynthesis, fatty acid degradation, and energy production. ACSL3 is primarily expressed in tissues like the liver and adipose tissue, where it is involved in fatty acid metabolism and lipid storage. ACSL4, on the other hand, is known for its significant role in the brain and in the regulation of inflammatory responses, as well as being implicated in the metabolism of polyunsaturated fatty acids. Dysregulation of ACSL3 and ACSL4 has been linked to several diseases, including metabolic disorders, cancer, and neurological diseases, making them important targets for therapeutic research and drug development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acyl-CoA synthetase 4; Arachidonate--CoA ligase; Fatty acid CoA ligase Acsl3; fatty-acid-Coenzyme A ligase, long-chain 3; fatty-acid-Coenzyme A ligase, long-chain 4; LACS 3; LACS 4; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 3; Long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; Long-chain-fatty-acid--CoA ligase 3; Long-chain-fatty-acid--CoA ligase 4; Medium-chain acyl-CoA ligase Acsl3
基因别名: ACS3; ACS4; ACSL3; ACSL4; FACL3; FACL4; LACS3; LACS4; MRX63; MRX68; PRO2194
UniProt ID: (Human) O95573, (Human) O60488
Entrez Gene ID: (Human) 2181, (Human) 2182
long-chain fatty acid metabolic process
fatty acid biosynthetic process
brain development
response to nutrient
response to organic cyclic compound
very-low-density lipoprotein particle assembly
long-chain fatty-acyl-CoA biosynthetic process
positive regulation of Golgi to plasma membrane protein transport
long-chain fatty acid import
positive regulation of secretion
positive regulation of phosphatidylcholine biosynthetic process
lipid metabolic process
triglyceride metabolic process
fatty acid transport
embryonic process involved in female pregnancy
dendritic spine development
response to interleukin-15
