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This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Actin-related protein 1B; ARP1; ARP1 actin-related protein 1 homolog B, centractin beta; ARP1B; Beta-centractin; centractin beta; yeast homolog B
基因别名: 2310066K23Rik; AA960180; ACTR1B; AI851923; ARP1B; CTRN2; PC3
UniProt ID: (Human) P42025, (Mouse) Q8R5C5
Entrez Gene ID: (Human) 10120, (Rat) 316333, (Mouse) 226977