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Invitrogen
ADAM8 Polyclonal Antibody
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ADAM8 Antibody (PA5-87946) in WB
Western blot analysis of ADAM8 in extracts of various cell lines. Samples were incubated with ADAM8 Polyclonal antibody (Product # PA5-87946) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.
产品信息
PA5-87946
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human ADAM8 (NP_0011003)
偶联物
形式
Liquid
浓度
2.336 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: BxPC-3, NIH/3T3; Cellular Location: Membrane, Single-pass type I membrane protein
Immunogen sequence: IAPSRPWALM EQYEVVLPWR LPGPRVRRAL PSHLGLHPER VSYVLGATGH NFTLHLRKNR DLLGSGYTET YTAANGSEVT EQPRGQDHCF YQGHVEGYPD SAASLSTCAG LRGFFQVGSD LHLIEPLDEG GEGGRHAVYQ AEHLLQTAGT CGVSDDSLGS LLGPRTAAVF RPRPGDSLPS RETRYVELYV VVDNAEFQML GSEAAVRHRV LEVVNHVDKL YQKLNFRVVL VGLEIWNSQD RFHVSPDPSV TLENLLTWQA RQRTRRHLHD NVQLITGVDF TGTT
靶标信息
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: a disintegrin and metallopeptidase domain 8; a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 8; ADAM; ADAM 8; ADAM metallopeptidase domain 8; ADAMs; CD156a; Cell surface antigen MS2; Disintegrin and metalloproteinase domain-containing protein 8; human leukocyte differentiation antigen; Macrophage cysteine-rich glycoprotein; metalloendopeptidases; MGC134985
基因别名: ADAM 8; ADAM8; CD156; CD156a; E430039A18Rik; MS2; RGD1566394
UniProt ID: (Human) P78325, (Mouse) Q05910
Entrez Gene ID: (Human) 101, (Mouse) 11501, (Rat) 499285
cell morphogenesis
angiogenesis
leukocyte migration involved in inflammatory response
positive regulation of acute inflammatory response
proteolysis
inflammatory response
positive regulation of protein processing
single organismal cell-cell adhesion
regulation of cell-cell adhesion
extracellular matrix disassembly
positive regulation of T cell differentiation in thymus
activation of MAPK activity involved in innate immune response
negative regulation of neuron apoptotic process
positive regulation of bone resorption
positive regulation of cell adhesion
lymphocyte chemotaxis
positive regulation of protein secretion
positive regulation of membrane protein ectodomain proteolysis
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein kinase B signaling
positive regulation of thymocyte apoptotic process
cellular response to hypoxia
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
positive regulation of neutrophil extravasation
positive regulation of fibronectin-dependent thymocyte migration
positive regulation of eosinophil migration
positive regulation of cellular extravasation
biological_process
positive regulation of inflammatory response
positive regulation of T cell migration
