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Invitrogen
ADAMTS13 Monoclonal Antibody (442323)
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ADAMTS13 Antibody (MA5-24167) in Flow
Flow cytometry of ADAMTS13 in HUVEC human umbilical vein endothelial cells. Samples were incubated in ADAMTS13 monoclonal antibody (Product # MA5-24167) or isotype control antibody followed by Phycoerythrin-conjugated Anti-Mouse IgG F(ab)2 Secondary Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin.
产品信息
MA5-24167
产品规格
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
442323
抗原
CHO-derived recombinant human ADAMTS13 isoform 1 Gln34-Trp688 (predicted)
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) ADAMTS1, rhADAMTS4, rhADAMTS5, or rhADAMTS-L1.2 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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