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Invitrogen
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Immunogen sequence: SIATLERLQS FRPLPEPLTV QLLTVPGEVF PPKVKYTFFV PNDVDFSMQS SKERATTNII QPLLHAQWVL
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 83%.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。