Invitrogen

ADORA2B Polyclonal Antibody

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ADORA2B Antibody in Western Blot (WB) — Western Blot analysis of ADORA2B in extracts of mouse brain using ADORA2B Polyclonal Antibody (Product # PA5-96008) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.

产品细节

Applications

Tested Dilution

Publications

免疫印迹 (WB)

1:500-1:2,000

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ADORA2B.

偶联物

Unconjugated

形式

Liquid

浓度

3.35 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2807810

产品详细信息

Immunogen sequence: AVDRYLAICV PLRYKSLVTG TRARGVIAVL WVLAFGIGLT PFLGWNSKDS ATNNCTEPWD GTTNESCCLV KCLFENVVPM SYMVYFNFFG CVLPPLLIML V; Positive Samples: Mouse brain; Cellular Location: Cell membrane, Multi-pass membrane protein

靶标信息

ADORA2B encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: A2b receptor; A2b, Rs; Adenosine receptor A2b; HGNC:264; netrin-1 receptor

基因别名: A2b; A2BAR; A2BR; AA2BR; ADORA2; ADORA2B; AI480866; AI605384

UniProt ID: (Human) P29275, (Mouse) Q60614

Entrez Gene ID: (Human) 136, (Mouse) 11541

分子生物学功能: G-protein coupled receptor

activation of MAPK activity adenosine receptor signaling pathway positive regulation of chronic inflammatory response to non-antigenic stimulus cellular defense response G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity JNK cascade excretion positive regulation of vascular endothelial growth factor production positive regulation of guanylate cyclase activity cellular response to extracellular stimulus positive regulation of chemokine production positive regulation of interleukin-6 production positive regulation of mast cell degranulation cellular protein metabolic process relaxation of vascular smooth muscle signal transduction positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of norepinephrine secretion positive regulation of steroid biosynthetic process positive regulation of cAMP biosynthetic process positive regulation of cGMP biosynthetic process negative regulation of collagen biosynthetic process positive regulation of catecholamine secretion regulation of angiogenesis positive regulation of vasodilation

参与通路

G-protein coupled adenosine receptor activity signal transducer activity G-protein coupled receptor activity