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Proteintech
ADPGK Polyclonal Antibody
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产品信息
15639-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ADPGK Fusion Protein Ag8105 (148-497 aa encoded by BC006112)
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: EFPGAQHYV GGNAALIGQK FAANSDLKVL LCGPVGPKLH ELLDDNVFVP PESLQEVDEF HLILEYQAGE EWGQLKAPHA NRFIFSHDLS NGAMNMLEVF VSSLEEFQPD LVVLSGLHMM EGQSKELQRK RLLEVVTSIS DIPTGIPVHL ELASMTNREL MSSIVHQQVF PAVTSLGLNE QELLFLTQSA SGPHSSLSSW NGVPDVGMVS DILFWILKEH GRSKSRASDL TRIHFHTLVY HILATVDGHW ANQLAAVAAG ARVAGTQACA TETIDTSRVS LRAPQEFMTS HSEAGSRIVL NPNKPVVEWH REGISFHFTP VLVCKDPIRT VGLGDAISAE GLFYSEVHPH Y (148-497 aa encoded by BC006112)
靶标信息
The ADPGK gene encodes ADP-dependent glucokinase, an enzyme distinct from the ATP-dependent hexokinases as it employs adenosine diphosphate (ADP) rather than ATP to phosphorylate glucose to glucose-6-phosphate. This gene, initially identified in archaeal species, has been co-opted into mammalian systems where it plays roles primarily in glycolytic processes. Structurally, the mammalian ADPGK differs from its archaeal counterpart, exemplified by the rearrangement of its secondary structures, such as the alpha2 and alpha3 helices. These helices are replaced by an extended beta-strand region, indicating evolutionary adaptations for function in higher organisms like mice. Although its precise physiological role remains partially defined, ADPGK is notably expressed in both hematopoietic lineages and tumor tissues, suggesting potential significance in cancer biology and energy metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ADP-dependent glucokinase; ADP-GK; ATP-dependent glucokinase; EC 2.7.1.147; RbBP-35
基因别名: 2610017G09Rik; ADP-GK; ADPGK; C77577; PSEC0260; RGD1306103
UniProt ID: (Human) Q9BRR6, (Mouse) Q8VDL4
Entrez Gene ID: (Human) 83440, (Mouse) 72141, (Rat) 315722
