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Proteintech
AEG-1/MTDH Polyclonal Antibody
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产品信息
13860-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AEG-1/MTDH-Specific Fusion Protein Ag4840 (233-582 aa encoded by BC045642)
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody got two bands about 70 kDa and 80 kDa in western blotting, possibly due to posttranslational modification. This antibody is specific to AEG-1/MTDH.
Immunogen sequence: EQLTTASFP VGSKKNKGDS HLNVQVSNFK SGKGDSTLQV SSGLNENLTV NGGGWNEKSV KLSSQISAGE EKWNSVSPAS AGKRKAEPSA WSQDTGDANT NGKDWGRSWS DRSIFSGIGS TAEPVSQSTT SDYQWDVSRN QPYIDDEWSG LNGLSSADPN SDWNAPAEEW GNWVDEERAS LLKSQEPIPD DQKVSDDDKE KGEGALPTGK SKKKKKKKKK QGEDNSTAQD TEELEKEIRE DLPVNTSKTR PKQEKAFSLK TISTSDPAEV LVKNSQPIKT LPPATSTEPS VILSKSDSDK SSSQVPPILQ ETDKSKSNTK QNSVPPSQTK SETSWESPKQ IKKKKKARRE T (233-582 aa encoded by BC045642)
靶标信息
Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 3D3/LYRIC; AEG-1; astrocyte elevated gene 1; Astrocyte elevated gene-1 protein; LYRIC; LYRIC/ MTDH; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein; Protein LYRIC
基因别名: 2610103J23Rik; 3D3; 3D3/Lyric; AEG-1; AEG1; AV353288; D8Bwg1112e; LYRIC; LYRIC/3D3; MTDH
UniProt ID: (Human) Q86UE4, (Mouse) Q80WJ7, (Rat) Q9Z1W6
Entrez Gene ID: (Human) 92140, (Mouse) 67154, (Rat) 170910
negative regulation of transcription from RNA polymerase II promoter
positive regulation of autophagy
lipopolysaccharide-mediated signaling pathway
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein kinase B signaling
bicellular tight junction assembly
