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Proteintech
AGAP2 Polyclonal Antibody
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产品信息
14690-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AGAP2 Fusion Protein Ag6142 (848-1192 aa encoded by BC028020)
偶联物
形式
Liquid
浓度
0.17 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MVKKQRRKK LTTPSKTEGS AGQAEEENFE FLIVSSTGQT WHFEAASFEE RDAWVQAIES QILASLQCCE SSKVKLRTDS QSEAVAIQAI RNAKGNSICV DCGAPNPTWA SLNLGALICI ECSGIHRNLG THLSRVRSLD LDDWPRELTL VLTAIGNDTA NRVWESDTRG RAKPSRDSSR EERESWIRAK YEQLLFLAPL STSEEPLGRQ LWAAVQAQDV ATVLLLLAHA RHGPLDTSVE DPQLRSPLHL AAELAHVVIT QLLLWYGADV AARDAQGRTA LFYARQAGSQ LCADILLQHG CPGEGGSAAT TPSAATTPSI TATPSPRRRS SAASVGRADA PVALV (848-1192 aa encoded by BC028020)
靶标信息
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AGAP-2; Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; centaurin gamma1; centaurin, gamma 1; Centaurin-gamma-1; Cnt-g1; FLJ16430; GGAP2; GTP-binding and GTPase activating protein 2; GTP-binding and GTPase-activating protein 2; nuclear GTPase PIKE; Phosphatidylinositol 3-kinase enhancer; phosphatidylinositol-3-kinase enhancer; phosphoinositide 3-kinase enhancer; PIKE
基因别名: AGAP-2; AGAP2; CENTG1; cnt-g1; GGAP2; KIAA0167; mKIAA0167; PIKE
UniProt ID: (Human) Q99490, (Mouse) Q3UHD9, (Rat) Q8CGU4
Entrez Gene ID: (Human) 116986, (Mouse) 216439, (Rat) 65218
small GTPase mediated signal transduction
positive regulation of phosphatidylinositol 3-kinase signaling
endosomal transport
actin cytoskeleton organization
positive regulation of mammary gland epithelial cell proliferation
negative regulation of protein catabolic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
regulation of phosphatidylinositol 3-kinase activity
positive regulation of protein kinase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
mammary gland alveolus development
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
protein transport
