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Rockland
AGAP2 Polyclonal Antibody
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产品信息
200-401-946
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
This protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to amino acids 1-836 of human AGAP2 protein.
偶联物
形式
Lyophilized
浓度
2 mg/mL
纯化类型
Protein A
保存液
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This protein A purified antibody is directed against human AGAP2 protein. A BLAST analysis was used to suggest cross reactivity with AGAP2 protein from mouse and rat based on 93% and 95% protein:protein homologies, respectively, with the immunizing sequence. Reactivity against homologues from other sources is not known.
靶标信息
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AGAP-2; Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; centaurin gamma1; centaurin, gamma 1; Centaurin-gamma-1; Cnt-g1; FLJ16430; GGAP2; GTP-binding and GTPase activating protein 2; GTP-binding and GTPase-activating protein 2; Phosphatidylinositol 3-kinase enhancer; phosphatidylinositol-3-kinase enhancer; phosphoinositide 3-kinase enhancer; PIKE
基因别名: AGAP-2; AGAP2; CENTG1; cnt-g1; GGAP2; KIAA0167; mKIAA0167; PIKE
UniProt ID: (Human) Q99490, (Mouse) Q3UHD9
Entrez Gene ID: (Human) 116986, (Mouse) 216439
small GTPase mediated signal transduction
positive regulation of phosphatidylinositol 3-kinase signaling
endosomal transport
actin cytoskeleton organization
positive regulation of mammary gland epithelial cell proliferation
negative regulation of protein catabolic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
regulation of phosphatidylinositol 3-kinase activity
positive regulation of protein kinase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
mammary gland alveolus development
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
protein transport
