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Invitrogen
AGO1/AGO2 Polyclonal Antibody
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AGO1/AGO2 Antibody (PA5-40075) in WB
Whole cell extracts of U2OS cells (40 µg) were analyzed by Western Blot using a AGO1 + AGO2 polyclonal antibody (Product # PA5-40075) at a dilution of 1:1,000 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right (expected size: 97 kDa); the marker (kDa) is shown on the left.
产品信息
PA5-40075
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide containing a sequence from the C-terminal part of both EIF2C1 and EIF2C2 corresponding to human IEF2C1/2 (eukaryotic translation initiation factor 2C1 and 2).
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
IEF2C1 and 2 are members of the Argonaute family. These proteins are involved in short-interfering-RNA-mediated gene silencing. This process is mediated by the RISC (RNA induced silencing complex), a multicomponent nuclease that is able to degrade double stranded RNAs. The mRNA degradation is triggered by the association of specific siRNAs with their homologous mRNAs. IEF2C2 has been shown to be essential for embryonic development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: argonaute 1, RISC catalytic component; argonaute 2, RISC catalytic component; Argonaute RISC catalytic component 1; Argonaute RISC catalytic component 2; Argonaute1; Argonaute2; cancer susceptibility candidate 7 (non-protein coding); eIF-2C 1; eIF-2C 2; eIF2C 1; Eukaryotic translation initiation factor 2C 1; Eukaryotic translation initiation factor 2C 2; eukaryotic translation initiation factor 2C, 1; eukaryotic translation initiation factor 2C, 2; Golgi Endoplasmic Reticulum protein 95 kDa; long intergenic non-protein coding RNA 980; PAZ Piwi domain protein; PPD; Protein argonaute-1; Protein argonaute-2; Protein slicer; Putative RNA-binding protein Q99; unnamed protein product
基因别名: AGO1; AGO2; CASC7; EIF2C; EIF2C1; EIF2C2; GERP95; hAgo1; LESKRES; LINC00980; NEDLBAS; PPD; Q10; Q99
UniProt ID: (Human) Q5TA57, (Human) Q9UKV8
Entrez Gene ID: (Human) 26523, (Human) 27161
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core binding
core promoter sequence-specific DNA binding
nucleic acid binding
RNA binding
double-stranded RNA binding
single-stranded RNA binding
endoribonuclease activity
protein binding
miRNA binding
RNA 7-methylguanosine cap binding
mRNA binding
translation initiation factor activity
nuclease activity
endonuclease activity
hydrolase activity
endoribonuclease activity, producing 5'-phosphomonoesters
siRNA binding
mRNA 3'-UTR AU-rich region binding
metal ion binding
endoribonuclease activity, cleaving siRNA-paired mRNA
endoribonuclease activity, cleaving miRNA-paired mRNA
mRNA cap binding
regulation of transcription, DNA-templated
translation
translational initiation
regulation of translation
post-embryonic development
gene expression
miRNA metabolic process
positive regulation of gene expression
production of siRNA involved in RNA interference
gene silencing by RNA
pre-miRNA processing
cytoplasmic mRNA processing body assembly
posttranscriptional gene silencing by RNA
production of miRNAs involved in gene silencing by miRNA
miRNA mediated inhibition of translation
mRNA cleavage involved in gene silencing by miRNA
negative regulation of amyloid precursor protein biosynthetic process
RNA stabilization
positive regulation of translation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
negative regulation of translational initiation
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
small RNA loading onto RISC
regulation of synapse maturation
mRNA cleavage involved in gene silencing by siRNA
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of trophoblast cell migration
nuclear-transcribed mRNA catabolic process
negative regulation of angiogenesis
regulation of mRNA stability
positive regulation of NIK/NF-kappaB signaling
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