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Proteintech
AGO2 Polyclonal Antibody
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产品信息
10686-1-AP
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AGO2 Fusion Protein Ag1032 (77-377 aa encoded by BC007633)
偶联物
形式
Liquid
浓度
0.16 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is specific to EIF2C2. EIF2C2 exists two isoforms and molecular weight of isoforms are 97 kDa and 94 kDa.
Immunogen sequence: TLSNLCLKI NVKLGGVNNI LLPQGRPPVF QQPVIFLGAD VTHPPAGDGK KPSIAAVVGS MDAHPNRYCA TVRVQQHRQE IIQDLAAMVR ELLIQFYKST RFKPTRIIFY RDGVSEGQFQ QVLHHELLAI REACIKLEKD YQPGITFIVV QKRHHTRLFC TDKNERVGKS GNIPAGTTVD TKITHPTEFD FYLCSHAGIQ GTSRPSHYHV LWDDNRFSSD ELQILTYQLC HTYVRCTRSV SIPAPAYYAH LVAFRARYHL VDKEHDSAEG SHTSGQSNGR DHQALAKAVQ VHQDTLRTMY FA (77-377 aa encoded by BC007633)
靶标信息
Ago proteins are broadly expressed in somatic cells, associate with miRNAs and are key actors in different RNA silencing pathways. However, only the Ago2 protein displays endonucleolytic or 'Slicer' activity and can therefore execute miRNA-directed cleavage of target mRNA, provided that the base-pairing between the Ago2-associated miRNA and the mRNA sequence is perfect. In case of partial complementarity, the Ago2 protein fails to cleave, but instead interferes with translation of the target mRNA via its translational repression activity. Ago2 has been shown to play a non-redundant role in small RNA guided gene silencing processes, including RNA interference, translation repression and heterochromatinization. As a core element of the RISC complex, AGO2 initiates the degradation of target mRNAs through its catalytic activity in gene silencing processes guided by siRNAs or miRNAs. In addition to mRNA degradation or gene silencing guided by miRNAs, Ago2 also acts as a RNA slicer in a Dicer-independent way, as well as a regulator of miRNA maturation. Over-expression of Ago2 has been correlated with several aspects of cancers, including tumor cell growth and the overall survival of cancer patients. Furthermore, gene disruption in the mouse demonstrated that the Ago2 protein is essential for embryonic development and a key regulator of B-lymphoid and erythroid development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
