Invitrogen

AIP2 Polyclonal Antibody

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AIP2 Antibody in Western Blot (WB) — Western Blot analysis of AIP2 in extracts of A-549 cells using AIP2 Polyclonal Antibody (Product # PA5-96126) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.

产品信息

PA5-96126

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 151-400 of human WWP2.

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.32 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2807928

产品详细信息

Immunogen sequence: VPNGSALTDG SQLPSRDSSG TAVAPENRHQ PPSTNCFGGR SRTHRHSGAS ARTTPATGEQ SPGARSRHRQ PVKNSGHSGL ANGTVNDEPT TATDPEEPSV VGVTSPPAAP LSVTPNPNTT SLPAPATPAE GEEPSTSGTQ QLPAAAQAPD ALPAGWEQRE LPNGRVYYVD HNTKTTTWER PLPPGWEKRT DPRGRFYYVD HNTRTTTWQR PTAEYVRNYE QWQSQRNQLQ GAMQHFSQRF LYQSSSASTD; Positive Samples: A-549; Cellular Location: Nucleus

靶标信息

This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: AIP2; atrophin-1 interacting protein 2; Atrophin-1-interacting protein 2; HECT-type E3 ubiquitin transferase WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2; WW domain-containing protein 2

基因别名: AIP2; WWP2; WWp2-like

UniProt ID: (Human) O00308

Entrez Gene ID: (Human) 11060

分子生物学功能: ubiquitin-protein ligase

功能

negative regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cellular protein modification process negative regulation of gene expression protein ubiquitination negative regulation of transporter activity regulation of ion transmembrane transport regulation of membrane potential protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter viral entry into host cell negative regulation of protein transport protein autoubiquitination protein K63-linked ubiquitination regulation of potassium ion transmembrane transporter activity

参与通路

RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding ubiquitin-protein transferase activity protein binding transcription factor binding ligase activity ubiquitin protein ligase activity