This antibody detects endogenous protein at a molecular weight of 95 kDa.
Purity is >95% by SDS-PAGE.
The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 95, also known as AKAP 8, is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney and skeletal muscle. During mitosis, AKAP 95 is recruited to the chromosomes and plays an essential role in mitotic progression. Characteristic of its family, AKAP 95 participates in PKA signaling through an interaction with the RII regulatory subunit. In addition, AKAP 95 forms a complex with HA95 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.
蛋白别名: A kinase (PRKA) anchor protein 8; A kinase anchor protein 8; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; AKAP 8; AKAP 95; AKAP-8; DKFZp586B1222
基因别名: 1200016A02Rik; AA673585; AKAP 95; AKAP-8; AKAP-95; AKAP8; AKAP95; AU015639
分子生物学功能: scaffold/adaptor protein