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Invitrogen
AKAP8L Polyclonal Antibody
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产品信息
PA5-114835
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human AKAP8L(Accession Q9ULX6), corresponding to amino acid residues Q8-N58.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total AKAP8L.
靶标信息
Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A kinase (PRKA) anchor protein 8-like; A-kinase anchor protein 8-like; AKAP8-like protein; HA95; HAP95; Helicase A-binding protein 95; helicase A-binding protein 95 kDa; Homologous to AKAP95 protein; neighbor of A-kinase anchoring protein 95; Neighbor of A-kinase-anchoring protein 95; neighbor of AKAP; Neighbor of AKAP95; testis tissue sperm-binding protein Li 90mP
基因别名: AKAP8L; HA95; HAP95; HRIHFB2018; NAKAP; NAKAP95
UniProt ID: (Human) Q9ULX6
Entrez Gene ID: (Human) 26993
transcription, DNA-templated
mRNA processing
mitotic chromosome condensation
biological_process
RNA splicing
regulation of mRNA export from nucleus
positive regulation of histone deacetylation
regulation of histone phosphorylation
cell cycle G2/M phase transition
positive regulation of transcription from RNA polymerase II promoter
nuclear envelope disassembly
