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AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: AKT1 kinase; AKT1m; Akt1m protein; AKT3 kinase; C-AKT; EC 2.7.11.1; murine thymoma viral (v-akt) oncogene homolog 1; PKB; PKB alpha; PKB gamma; Protein kinase Akt-3; Protein kinase B; Protein kinase B alpha; Protein kinase B gamma; protein kinase B, gamma; protein kinase B-alpha; Proto-oncogene c-Akt; rac protein kinase alpha; RAC protein kinase alpha RAC-PK alpha; RAC-alpha serine/threonine-protein kinase; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-alpha; RAC-PK-gamma; related to A and C kinases; serine-threonine protein kinase; STK-2; Thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); v-akt murine thymoma viral oncogene-like protein 1
基因别名: AI851531; AKT; AKT1; AKT3; CWS6; D930002M15Rik; MPPH; MPPH2; Nmf350; PKB; PKB-ALPHA; PKB-GAMMA; PKB/Akt; PKBalpha; PKBG; PRKBA; PRKBG; RAC; RAC-ALPHA; RAC-gamma; RAC-PK-gamma; STK-2
UniProt ID: (Human) P31749, (Human) Q9Y243, (Mouse) P31750, (Rat) P47196, (Rat) Q63484, (Mouse) Q9WUA6
Entrez Gene ID: (Human) 207, (Human) 10000, (Rabbit) 100353706, (Mouse) 11651, (Rat) 24185, (Rat) 29414, (Mouse) 23797