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Invitrogen
ALAD Polyclonal Antibody
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ALAD Antibody (PA5-54310) in IHC (P)
Immunohistochemistry analysis of ALAD in human kidney, liver, pancreas and skeletal muscle. Samples were incubated with ALAD polyclonal antibody (Product # PA5-54310). Shows similar protein distribution across tissues to independent ALAD antibody (Product # PA5-54564) (B).
产品信息
PA5-54310
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: GCQVVAPSDM MDGRVEAIKE ALMAHGLGNR VSVMSYSAKF ASCFYGPFRD AAKSSPAFGD RRCYQLPPGA RGLALRAVDR D
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
靶标信息
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternatively spliced transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALADH; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehydratase; Porphobilinogen synthase; testicular tissue protein Li 95
基因别名: ALAD; ALADH; PBGS
UniProt ID: (Human) P13716
Entrez Gene ID: (Human) 210
response to hypoxia
protoporphyrinogen IX biosynthetic process
heme biosynthetic process
response to oxidative stress
response to herbicide
response to iron ion
response to zinc ion
response to aluminum ion
response to ionizing radiation
response to vitamin B1
response to selenium ion
response to activity
response to cobalt ion
response to lipopolysaccharide
response to vitamin E
response to drug
response to amino acid
response to ethanol
response to arsenic-containing substance
response to cadmium ion
response to mercury ion
protein homooligomerization
response to glucocorticoid
response to methylmercury
response to platinum ion
response to fatty acid
cellular response to lead ion
cellular response to interleukin-4
