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NeoBiotechnologies
ALCAM (Activated Leukocyte Cell Adhesion Molecule)/CD166 Recombinant Mouse Monoclonal Antibody (rMOG/07)
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ALCAM (Activated Leukocyte Cell Adhesion Molecule)/CD166 Antibody (214-MSM3-P1) in IHC (P)
Formalin-fixed, paraffin-embedded human parathyroid gland stained with ALCAM/CD166 Recombinant Mouse Monoclonal Antibody (rMOG/07). Inset: PBS instead of primary antibody; secondary only negative control.
产品信息
214-MSM3-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
rMOG/07
抗原
Raised against a 200 amino acid portion of human CD166.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Cell membrane.
Positive control: Human tonsil, spleen, colon or parathyroid gland.
Tissue specificity: Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422).
靶标信息
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activated leukocyte cell adhesion molecule; CD166; CD166 antigen; FLJ38514; MGC71733
基因别名: ALCAM; CD166; MEMD
UniProt ID: (Human) Q13740
Entrez Gene ID: (Human) 214
