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Proteintech
ALKBH4 Polyclonal Antibody
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产品信息
19882-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ALKBH4 Fusion Protein Ag8041 (1-302 aa encoded by BC002820)
偶联物
形式
Liquid
浓度
0.32 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAAAAAETP EVLRECGCKG IRTCLICERQ RGSDPPWELP PAKTYRFIYC SDTGWAVGTE ESDFEGWAFP FPGVMLIEDF VTREEEAELV RLMDRDPWKL SQSGRRKQDY GPKVNFRKQK LKTEGFCGLP SFSREVVRRM GLYPGLEGFR PVEQCNLDYC PERGSAIDPH LDDAWLWGER LVSLNLLSPT VLSMCREAPG SLLLCSAPSA APEALVDSVI APSRSVLCQE VEVAIPLPAR SLLVLTGAAR HQWKHAIHRR HIEARRVCVT FRELSAEFGP GGRQQELGQE LLRIALSFQG RPV (1-302 aa encoded by BC002820)
靶标信息
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: alkB homolog 4, lysine demthylase; alkB, alkylation repair homolog 4; Alkylated DNA repair protein alkB homolog 4; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; DNA N6-methyl adenine demethylase ALKBH4; Lysine-specific demethylase ALKBH4; probable alpha-ketoglutarate-dependent dioxygenase ABH4
基因别名: 2010004B12Rik; ABH4; Abj4; ALKBH4; RGD1308608
UniProt ID: (Human) Q9NXW9, (Mouse) Q9D8F1
Entrez Gene ID: (Human) 54784, (Rat) 288587, (Mouse) 72041
actin binding
protein binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
demethylase activity
metal ion binding
sulfonate dioxygenase activity
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
oxidoreductase
oxygenase
metabolite interconversion enzyme
