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产品信息
PA5-64883
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫细胞化学 (ICC/IF) |
0.25-2 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant Human ALX4 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.05 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.2, with 40% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2664723 |
产品详细信息
Immunogen sequence: SPFRAFPGGDK FGTTFLSAAA KAQGFGDAKS RARYGAGQQD LATPLESGAG ARGSFNKFQP QPSTPQPQPS PQPQPQQQQP QPQPPAQPHL YLQRGACKTP PDGSLKLQEG S
Highest antigen sequence identity to the following orthologs - mouse 80%, rat 81%.
靶标信息
This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aristaless-like homeobox 4; Homeobox protein aristaless-like 4; homeodomain transcription factor ALX4
基因别名: ALX4; CRS5; FND2; KIAA1788
UniProt ID: (Human) Q9H161
Entrez Gene ID: (Human) 60529
分子生物学功能:
homeodomain transcription factor
skeletal system development
hair follicle development
transcription from RNA polymerase II promoter
muscle organ development
post-embryonic development
anterior/posterior pattern specification
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
embryonic digit morphogenesis
regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
embryonic skeletal system morphogenesis
palate development
