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Proteintech
AMIGO2 Polyclonal Antibody
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产品信息
14076-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AMIGO2 Fusion Protein Ag5200 (30-399 aa encoded by BC047595)
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: TVTVGPGAS GVCPTACICA TDIVSCTNKN LSKVPGNLFR LIKRLDLSYN RIGLLDSEWI PVSFAKLNTL ILRHNNITSI STGSFSTTPN LKCLDLSSNK LKTVKNAVFQ ELKVLEVLLL YNNHISYLDP SAFGGLSQLQ KLYLSGNFLT QFPMDLYVGR FKLAELMFLD VSYNRIPSMP MHHINLVPGK QLRGIYLHGN PFVCDCSLYS LLVFWYRRHF SSVMDFKNDY TCRLWSDSRH SRQVLLLQDS FMNCSDSIIN GSFRALGFIH EAQVGERLMV HCDSKTGNAN TDFIWVGPDN RLLEPDKEME NFYVFHNGSL VIESPRFEDA GVYSCIAMNK QRLLNETVDV TINVSNFTVS RSHAHEAFNT A (30-399 aa encoded by BC047595)
靶标信息
A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adhesion molecule with Ig-like domain 2; alivin 1; Alivin-1; AMIGO-2; AMIGO2; amigo2 {ECO:0000312|EMBL:AAO48951.1}; amphoterin induced gene 2; amphoterin induced gene and ORF 2; Amphoterin-induced protein 2; DEGA; differentially expressed in gastric adenocarcinoma; Differentially expressed in gastric adenocarcinomas; transmembrane protein AMIGO2
基因别名: AI415330; ALI1; AMIGO-2; AMIGO2; AW208913; DEGA
UniProt ID: (Human) Q86SJ2, (Mouse) Q80ZD9, (Rat) Q7TNJ4
Entrez Gene ID: (Human) 347902, (Mouse) 105827, (Rat) 300186
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of synapse assembly
cell adhesion
brain development
cell-cell adhesion
