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AMPK alpha 2 Polyclonal Antibody

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说明书
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AMPK alpha 2 Polyclonal Antibody

产品信息

18167-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
查看38篇已发表文章 38篇已发表文章

免疫组化 (IHC)

-
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免疫组化（石蜡） (IHC (P))

1:100-1:400
-

免疫细胞化学 (ICC/IF)

1:10-1:100
查看3篇已发表文章 3篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg
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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

AMPK alpha 2 Fusion Protein Ag12796 (215-552 aa encoded by BC069680)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.19 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: DDEHVPTLF KKIRGGVFYI PEYLNRSVAT LLMHMLQVDP LKRATIKDIR EHEWFKQDLP SYLFPEDPSY DANVIDDEAV KEVCEKFECT ESEVMNSLYS GDPQDQLAVA YHLIIDNRRI MNQASEFYLA SSPPSGSFMD DSAMHIPPGL KPHPERMPPL IADSPKARCP LDALNTTKPK SLAVKKAKWH LGIRSQSKPY DIMAEVYRAM KQLDFEWKVV NAYHLRVRRK NPVTGNYVKM SLQLYLVDNR SYLLDFKSID DEVVEQRSGS STPQRSCSAA GLHRPRSSFD STTAESHSLS GSLTGSLTGS TLSSVSPRLG SHTMDFFEMC ASLITTLAR (215-552 aa encoded by BC069680)

靶标信息

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: 5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; ACACA kinase; Acetyl-CoA carboxylase kinase; AMP-activated protein kinase; AMP-activated protein kinase alpha-2 subunit variant 2; AMP-activated protein kinase alpha-2 subunit variant 3; AMP-activated protein kinase alpha-2 variant B; AMPK alpha 2; AMPK alpha-2 chain; AMPK subunit alpha-2; AMPK-alpha-2 chain; EC 2.7.11.1; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; prkaa2; protein kinase, AMP-activated, alpha 2 catalytic subunit

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基因别名: 2310008I11Rik; A830082D05; AMPK; AMPK2; AMPKa2; AMPKalpha2; PRKAA; PRKAA2

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UniProt ID: (Human) P54646, (Rat) Q09137, (Mouse) Q8BRK8

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Entrez Gene ID: (Human) 5563, (Rat) 78975, (Mouse) 108079

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功能
chromatin binding protein kinase activity protein serine/threonine kinase activity AMP-activated protein kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding histone serine kinase activity metal ion binding [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity [acetyl-CoA carboxylase] kinase activity protein binding, bridging nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
参与通路
transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation fatty acid biosynthetic process cholesterol biosynthetic process carnitine shuttle response to stress cell cycle arrest signal transduction lipid biosynthetic process positive regulation of autophagy response to muscle activity Wnt signaling pathway macroautophagy positive regulation of macroautophagy regulation of macroautophagy cellular response to nutrient levels negative regulation of TOR signaling histone-serine phosphorylation intracellular signal transduction cellular response to drug cellular response to glucose starvation regulation of fatty acid biosynthetic process glucose homeostasis regulation of circadian rhythm negative regulation of apoptotic process positive regulation of glycolytic process rhythmic process fatty acid homeostasis cellular response to prostaglandin E stimulus regulation of signal transduction by p53 class mediator regulation of energy homeostasis autophagy response to activity regulation of lipid metabolic process response to caffeine protein heterooligomerization cellular response to organonitrogen compound lipid metabolic process fatty acid metabolic process steroid biosynthetic process steroid metabolic process cholesterol metabolic process regulation of gene expression sterol biosynthetic process phosphorylation chromatin modification
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