Synthetic peptide sequence: 32-68aa, DRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLE.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
AMPK beta 1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
蛋白别名: 5'-AMP-activated protein kinase beta-1 subunit; 5'-AMP-activated protein kinase subunit beta-1; AAKB1; AMP-activated protein kinase beta subunit; AMPK beta -1 chain; AMPK beta 1; AMPK subunit beta-1; AMPK-beta1; AMPKb; kinase AMPK-beta1; kinase pAMPK; pAMPK; protein kinase, AMP-activated, beta 1 non-catalytic subunit; protein kinase, AMP-activated, noncatalytic, beta-1
基因别名: AMPK; HAMPKb; PRKAB1
UniProt ID: (Human) Q9Y478
Entrez Gene ID: (Human) 5564
分子生物学功能: kinase modulator