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Immunogen sequence: MGNTTSDRV SGERHGAKAA RSEGAGGHAP GKEHKIMVGS TDDPSVFSLP DSKLPGDKEF VSWQQDLEDS VKPTQQARPT VIRWSEGGKE VFISGSFNNW STKIPLIKSH NDFVAILDLP EGEHQYKFFV DGQWVHDPSE PVVTSQLGTI NNLIHVKKSD FEVFDALKLD SMESSETSCR DLSSSPPGPY GQEMYAFRSE ERFKSPPILP PHLLQVILNK DTNISCDPAL LPEPNHVMLN HLYALSIKDS VMVLSATHRY KKKYVTTLLY KPI (1-272 aa encoded by BC053610)
AMPK Beta 2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 5'-AMP-activated protein kinase subunit beta-2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-catalytic subunit; AMP-activated protein kinase beta-2 regulatory subunit; AMPK beta 2; AMPK beta-2 chain; AMPK subunit beta-2; AMPKbeta2; protein kinase, AMP-activated, beta 2 non-catalytic subunit
基因别名: 5730553K21Rik; AW049591; BB124140; PRKAB2
UniProt ID: (Human) O43741, (Rat) Q9QZH4, (Mouse) Q6PAM0
Entrez Gene ID: (Human) 5565, (Rat) 64562, (Mouse) 108097
分子生物学功能: protein-binding activity modulator kinase modulator