PA1-1053 detects fasting-induced adipose factor (FIAF) from rat and mouse adipose tissue.
PA1-1053 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~50 kDa protein representing FIAF from rat adipose tissue extracts.
The PA1-1053 immunogen is a synthetic peptide corresponding to residues C(80) Q G P K G K D A P F K D S E(94) of mouse FIAF.
PA1-1053 can be used with blocking peptide PEP-178.
Angiopoietin-like protein 4 (ANGPTL4), is a secreted protein selectively expressed in adipose tissue, liver, and placenta1-3 that plays a variety of roles in vivo, ranging from adipogenesis to angiogenesis to carcinogenesis. The expression of ANGPTL4 is also under nutritional and hormonal control. ANGPTL4 has been observed to induce a strong pro-angiogenic response independent of vascular endothelial growth factor (VEGF), and its expression has been described in hypoxic human tissues as well as a variety of cancers, including liposarcoma, hepatocellular carcinoma, and conventional renal cell carcinoma.
蛋白别名: 425O18-1; Angiopoietin-like protein 4; Angiopoietin-related protein 4; ANGPTL2; ANGPTL4 C-terminal chain; ANGPTL4 N-terminal chain; Fasting-i; Fasting-induced adipose factor; fibrinogen/angiopoietin-related protein; Hepatic fibrinogen/angiopoietin-related protein; HFARP; major histocompatibility complex region NG27; Secreted protein Bk89
基因别名: Angptl4; Arp4; Bk89; Farp; Fiaf; Hfarp; Ng27; Pgar; Pgarg; Pp1158
分子生物学功能: intercellular signal molecule