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Proteintech
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Immunogen sequence: DLSSQEGLQ RLEEYLTQQE IGKKAQQETG EREASCRDKA TTSGSNSISV RAFLDEDDMN LEEIKNRQNA ARNNSPPTVG AFGHTRCSAF PLEQEADLIE AAEPGGPHSS RNGLCHPLNH SRTLAGKRPK APHGEEAHLP PVSDLTVEFD KLNLQNIGRS VSKTPDESTK TKDQILTSRI NAVERDLLEP SPADQLGNGH RRTESEMSAR IAKMSLSPSS PRHEDQLEVT REPARRLFLF GEEPSKLDQD VLAALECADV DPHQFPAVHR WKSAVLCYSP SDRQSWPSPA VKGRFKSQLP DLSGPHSYSP GRNSVAGSNP AKPGLGSPGR YSPVHGSQLR RMARLAELAA L (589-938 aa encoded by BC043157)
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Ankyrin repeat and LEM domain-containing protein 2; LEM domain containing 7; LEM domain-containing protein 4
基因别名: ANKLE2; KIAA0692; LEM4; LEMD7; MCPH16
UniProt ID: (Human) Q86XL3
Entrez Gene ID: (Human) 23141