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Invitrogen
ANKLE2 Polyclonal Antibody
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产品信息
PA5-51973
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SETVNKERAN SYKNPRTQDL TAKLRKAVEK GEEDTFSDLI WSNPRYLIGS GDNPTIVQEG CRYNVMHVAA KENQASICQL TLDVLENPDF MRLMYPDDDE AMLQKRIRYV VDLYLNTPDK MGYDTPLHFA CKFGNADVVN VLSSH
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 90%.
靶标信息
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ankyrin repeat and LEM domain-containing protein 2; LEM domain containing 7; LEM domain-containing protein 4
基因别名: ANKLE2; KIAA0692; LEM4; LEMD7; MCPH16
UniProt ID: (Human) Q86XL3
Entrez Gene ID: (Human) 23141
mitotic nuclear division
mitotic nuclear envelope reassembly
central nervous system development
regulation of protein phosphatase type 2A activity
positive regulation of protein dephosphorylation
negative regulation of phosphorylation
negative regulation of apoptotic process
regulation of catalytic activity
cell division
