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Proteintech
APC2 Polyclonal Antibody
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产品信息
13559-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
APC2 Fusion Protein Ag4427 (524-822 aa encoded by BC032503)
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: ADRLLHQFS FSPEREIRNV ELLKLRFGEA PMHFCEVMLK DMADSRRINA NIREEDEKRP AEEQPPFGVY AVILSSEFWP PFKDEKLEVP EDIRAALEAY CKKYEQLKAM RTLSWKHTLG LVTMDVELAD RTLSVAVTPV QAVILLYFQD QASWTLEELS KAVKMPVALL RRRMSVWLQQ GVLREEPPGT FSVIEEERPQ DRDNMVLIDS DDESDSGMAS QADQKEEELL LFWTYIQAML TNLESLSLDR IYNMLRMFVV TGPALAEIDL QELQGYLQKK VRDQQLVYSA GVYRLPKNCS (524-822 aa encoded by BC032503)
靶标信息
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: adenomatosis polyposis coli 2; adenomatous polyposis coli like; Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APC-like
基因别名: AI852447; APC2; APCL; R75424
UniProt ID: (Human) O95996
Entrez Gene ID: (Human) 10297, (Rat) 299611, (Mouse) 23805
biological_process
Wnt signaling pathway
negative regulation of catenin import into nucleus
negative regulation of canonical Wnt signaling pathway
cell fate specification
negative regulation of microtubule depolymerization
pattern specification process
cell proliferation
cell migration
regulation of cell differentiation
positive regulation of protein catabolic process
