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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
4-6 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Bovine, Dog, Horse, Human, Marsupial, Non-human primate, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide (96 KADEGLASLSEDGRSPIS 113) of APH1A protein. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.5 mg/mL |
纯化类型 |
Protein A |
保存液 |
PBS with 0.05% BSA |
内含物 |
0.05% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2540966 |
APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: anterior pharynx defective 1 homolog A; anterior pharynx defective 1a homolog; aph-1 homolog A, gamma secretase subunit; APH-1a; Aph-1alpha; APH1A gamma secretase subunit; Gamma-secretase subunit APH-1A; Presenilin-stabilization factor; RP4-790G17.3
基因别名: 6530402N02Rik; APH-1; APH-1A; APH1; APH1A; CGI-78; PSF; RGD1311546; UNQ579/PRO1141
UniProt ID: (Human) Q96BI3
Entrez Gene ID: (Horse) 100054581, (Bovine) 539247, (Dog) 100855839, (Human) 51107, (Rat) 365872
分子生物学功能:
protease
