Invitrogen

APIP Polyclonal Antibody

产品信息

PA5-50193

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:200-1:1,000	-
免疫组化（石蜡） (IHC (P))	1:25-1:100	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Fusion protein corresponding to a region derived from internal residues of human Probable methylthioribulose-1-phosphate dehydratase
偶联物	Unconjugated
形式	Liquid
浓度	1.6 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2635646

产品详细信息

The antibody detects endogenous levels of total APIP protein.

靶标信息

The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf 1 (for apoptosis protease-activating factor 1). Apaf 1 binds to cytochrome c (Apaf 2) and Caspase-9 (Apaf 3), which leads to Caspase-9 activation. Activated Caspase-9 in turn cleaves and activates Caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Recently, Cho et al (4) have identified a new Apaf 1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf 1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: APAF1-interacting protein; APIP; CG129; dJ179L10.2; hAPIP; Methylthioribulose-1-phosphate dehydratase; monocyte macrophage 19; Monocyte/macrophage protein 19; MTRu-1-P dehydratase; probable methylthioribulose-1-phosphate dehydratase

基因别名: APIP; APIP2; CGI-29; CGI29; hAPIP; MMRP19

UniProt ID: (Human) Q96GX9, (Mouse) Q9WVQ5

Entrez Gene ID: (Human) 51074, (Mouse) 56369

分子生物学功能: dehydratase lyase metabolite interconversion enzyme